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KMID : 0882420160900030248
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Korean Journal of Medicine
2016 Volume.90 No. 3 p.248 ~ p.252
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Two Cases of Distal Renal Tubular Acidosis accompanied by Sjogren’s Syndrome
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강은정:Kang Eun-Jeong
박석우:Park Seok-Woo/박세훈:Park Se-Hoon/이하정:Lee Ha-Jeong/한진석:Han Jin-Suk/주권욱:Joo Kwon-Wook
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Abstract
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Renal tubular acidosis (RTA) is a syndrome characterized by hyperchloremic metabolic acidosis and an inability to excrete highly acid urine, in which the impaired acid excretion is disproportional to the reduction in the glomerular filtration rate. Distal renal tubular acidosis (dRTA) is frequently associated with immune-mediated disease, including Sjogren’s syndrome. Sjogren’s syndrome is a systemic autoimmune disease that mainly affects exocrine glands, such as the lacrimal and salivary glands, resulting in xerophthalmia and xerostomia. Extraglandular manifestations are frequent and may include renal involvement. Recently, we experienced two cases of renal tubular acidosis in patients with Sjogren’s syndrome. The first patient had lower extremity weakness and hypokalemia and the second had nephrocalcinosis. We discuss the frequency and pathogenesis of dRTA in Sjogren’s syndrome.
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KEYWORD
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Sjogren’s syndrome, Acidosis, Renal tubular, Hypokalemia, Nephrocalcinosis
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